Doktora Tezi
Oral Yoldan Uygulanmak Üzere Ritonavir Nanosüspansiyon Formülasyonunun Geliştirilmesi ve İn Vitro/ İn Vivo Değerlendirilmesi, Doktora Tezi, 2017.
Askerlik
Dr. Ecz. Tğm., Kalite Güvence Birim Amiri, T.C. Milli Savunma Bakanlığı Askeri Fabrikalar Genel Müdürlüğü, İlaç Fabrikası Müdürlüğü, Ankara, 02.05.2018 - 02.05.2019.
Projeler
"Nanosüspansiyon Bazlı Etodolak Jel Formülasyonunun Geliştirilmesi ve in vitro/ in vivo Değerlendirilmesi", TÜBİTAK 3001, Proje Başlangıç Tarihi: 15.05.2019, Proje Bitiş Tarihi: 24.07.2020, Proje No: 118S718, Proje Yürütücüsü.
"Siklosporinin Yeni Oral Formülasyonunun Geliştirilmesi ve İn vitro/ İn vivo Değerlendirilmesi", Gazi Üniversitesi Bilimsel Araştırma Projeleri, Proje Başlangıç Tarihi: 28.09.2017, Proje Bitiş Tarihi: 03.02.2020, Proje No 02/2017-14, Araştırmacı.
2016/17 Newton Fund, Royal Academy of Engineering, Leaders In Innovation Fellowships, TÜBİTAK 2239, February 13-24, 2017, The Hoxton Holborn, London, UK.
"Saç Bakımında Bitkisel Kaynaklı Ürün Geliştirilmesi", PharmaSet Sağlık Ar-Ge, KOSGEB Ar-Ge ve İnovasyon Programı, Proje Başlangıç Tarihi: 2016, Proje Bitiş Tarihi: 2017, Proje Formülasyon ve Yazım Danışmanı (Fiber Farma).
"Nanokristal Teknolojisi Ile Ağızda Dağılan Tabletlerin Tasarımla Kalite (Qbd) Uygulamaları Ile Geliştirilmesi Ve Değerlendirilmesi", TÜBİTAK 1002, Proje Başlangıç Tarihi 2016, Proje Bitiş Tarihi: 2017, Proje No 215S920, Bursiyer.
"Akneye Meyilli Ciltlerde ve Cilt Bakımında Etkili Yeni Nanoteknolojik Ürün Geliştirilmesi", Bilim, Teknoloji ve Sanayi Bakanlığı Teknogirişim Projesi, Proje Başlangıç Tarihi: 08/06/2015, Proje Bitiş Tarihi: 12/10/2016, Proje No 0104.TGSD, Proje Yürütücüsü.
"HIV Proteaz İnhibitörü Ritonavirin Yeni Nanosüspansiyon Formülasyonunun Geliştirilmesi ve İn Vitro/ İn Vivo Değerlendirilmesi", TÜBİTAK 1001, Proje Başlangıç Tarihi: 01/03/2014, Proje Bitiş Tarihi: 01/12/2016, Proje Yürütücüsü: Prof. Dr. Nevin Çelebi, Proje No 113S842, Bursiyer.
"Siklosporinin Yeni Oral Formülasyonunun Geliştirilmesi ve İn vitro/ İn vivo Değerlendirilmesi", Gazi Üniversitesi Bilimsel Araştırma Projeleri, Proje Başlangıç Tarihi: 28.09.2017, Proje Bitiş Tarihi: 03.02.2020, Proje No 02/2017-14, Araştırmacı.
2016/17 Newton Fund, Royal Academy of Engineering, Leaders In Innovation Fellowships, TÜBİTAK 2239, February 13-24, 2017, The Hoxton Holborn, London, UK.
"Saç Bakımında Bitkisel Kaynaklı Ürün Geliştirilmesi", PharmaSet Sağlık Ar-Ge, KOSGEB Ar-Ge ve İnovasyon Programı, Proje Başlangıç Tarihi: 2016, Proje Bitiş Tarihi: 2017, Proje Formülasyon ve Yazım Danışmanı (Fiber Farma).
"Nanokristal Teknolojisi Ile Ağızda Dağılan Tabletlerin Tasarımla Kalite (Qbd) Uygulamaları Ile Geliştirilmesi Ve Değerlendirilmesi", TÜBİTAK 1002, Proje Başlangıç Tarihi 2016, Proje Bitiş Tarihi: 2017, Proje No 215S920, Bursiyer.
"Akneye Meyilli Ciltlerde ve Cilt Bakımında Etkili Yeni Nanoteknolojik Ürün Geliştirilmesi", Bilim, Teknoloji ve Sanayi Bakanlığı Teknogirişim Projesi, Proje Başlangıç Tarihi: 08/06/2015, Proje Bitiş Tarihi: 12/10/2016, Proje No 0104.TGSD, Proje Yürütücüsü.
"HIV Proteaz İnhibitörü Ritonavirin Yeni Nanosüspansiyon Formülasyonunun Geliştirilmesi ve İn Vitro/ İn Vivo Değerlendirilmesi", TÜBİTAK 1001, Proje Başlangıç Tarihi: 01/03/2014, Proje Bitiş Tarihi: 01/12/2016, Proje Yürütücüsü: Prof. Dr. Nevin Çelebi, Proje No 113S842, Bursiyer.
Ödüller
Gazi Üniversitesi Rektörlüğü Yayın Ödülü, 2020.
Gazi Üniversitesi Rektörlüğü Yayın ve Patent Ödülü, 2019.
Gazi Üniversitesi Rektörlüğü Patent Ödülü, 2018.
Gazi Üniversitesi Rektörlüğü Yayın Ödülü, 2017.
2016/17 Final Pitch Session Third Place, Royal Academy of Engineering, Leaders In Innovation Fellowships, London, UK.
Gazi Üniversitesi Rektörlüğü Proje Ödülü, 2016.
İş Güvenliği ve Savunma Sanayine Yönelik Kanama Durdurucu Nanoteknolojik Örtü Geliştirilmesi, Gazi Üniversitesi Teknoloji Transfer Ofisi - Halkbank, Fikirden İcraata 2015, Birincilik Ödülü.
Akne ve Uçuk Tedavisinde Etkili Resveratrolün Kombine Yöntemlerle Yeni Nanofiber Formülasyonunun Geliştirilmesi, Gazi Üniversitesi Teknoloji Transfer Ofisi - Halkbank, Fikirden İcraata 2014, Birinci Mansiyon Ödülü.
Gazi Üniversitesi Rektörlüğü Yayın ve Patent Ödülü, 2019.
Gazi Üniversitesi Rektörlüğü Patent Ödülü, 2018.
Gazi Üniversitesi Rektörlüğü Yayın Ödülü, 2017.
2016/17 Final Pitch Session Third Place, Royal Academy of Engineering, Leaders In Innovation Fellowships, London, UK.
Gazi Üniversitesi Rektörlüğü Proje Ödülü, 2016.
İş Güvenliği ve Savunma Sanayine Yönelik Kanama Durdurucu Nanoteknolojik Örtü Geliştirilmesi, Gazi Üniversitesi Teknoloji Transfer Ofisi - Halkbank, Fikirden İcraata 2015, Birincilik Ödülü.
Akne ve Uçuk Tedavisinde Etkili Resveratrolün Kombine Yöntemlerle Yeni Nanofiber Formülasyonunun Geliştirilmesi, Gazi Üniversitesi Teknoloji Transfer Ofisi - Halkbank, Fikirden İcraata 2014, Birinci Mansiyon Ödülü.
Yayınlar
Alptug Karakucuk, Serdar Tort, "Preparation, characterization and antimicrobial activity evaluation of electrospun PCL nanofiber composites of resveratrol nanocrystals", Pharmaceutical Development and Technology, DOI: 10.1080/10837450.2020.1805761.
Alptug Karakucuk, Emine Tashan, Naile Ozturk, Nevin Celebi, "In Vitro Caco-2 Cell Permeability Studies of Ziprasidone Hydrochloride Monohydrate Nanocrystals", Turkish Journal of Pharmaceutical Sciences, 10.4274/tjps.galenos.2020.67366.
Diren Sarısaltık-Yasin, Alev Arslanturk-Bingul, Alptug Karakucuk, Zeynep Safak Teksin, "Development and validation of an HPLC method using an experimental design for analysis of amlodipine besylate and enalapril maleate in a fixed dose combination", Turkish Journal of Pharmaceutical Sciences, 10.4274/tjps.galenos.2020.89725.
Alptug Karakucuk, Nevin Celebi, "Investigation of Formulation and Process Parameters of Wet Media Milling to Develop Etodolac Nanosuspensions", Pharmaceutical Research, 2020, 37, 1-18.
Emine Tashan, Alptug Karakucuk, Nevin Celebi, " Development of Nanocrystal Ziprasidone Orally Disintegrating Tablets: Optimization by Using Design of Experiment and In Vitro Evaluation", AAPS PharmSciTech, 2020, 21, 1-12.
Ayşe N. Oktay, Sibel Ilbasmis-Tamer, Alptug Karakucuk, Nevin Celebi, "Screening of stabilizing agents to optimize flurbiprofen nanosuspensions using experimental design", Journal of Drug Delivery Science and Technology, 2020, 101690.
Emine Tashan, Alptug Karakucuk, Nevin Celebi, "Optimization and in vitro evaluation of ziprosidone nanosuspensions produced by a top-down approach", Journal of Drug Delivery Science and Technology, 2019, 52, 37-45.
Alptug Karakucuk, Zeynep Safak Teksin, Hakan Eroglu, Nevin Celebi, “Evaluation of improved oral bioavailability of ritonavir nanosuspension”, European Journal of Pharmaceutical Sciences, 2019, 131, 153-158.
Zarith Asyikin Abdul Aziz, Akil Ahmad, Siti Hamidah Mohd Setapar, Alptug Karakucuk, Muhammad Mohsin Azim, David Lokhat, Mohammad Amjad Kamal, Ghulam Md. Ashraf, "Essential Oils: Extraction Techniques, Pharmaceutical And Therapeutic Ptential - A Review", Current Drug Metabolism, 2018, 19(13), 1100-1110, DOI:10.2174/1389200219666180723144850.
Ayşe N. Oktay, Alptug Karakucuk, Sibel Ilbasmis-Tamer, Nevin Celebi, "Dermal flurbiprofen nanosuspensions: Optimization with design of experiment approach and in vitro evaluation", European Journal of Pharmaceutical Sciences, 2018, 122, 254-263.
Sıla Gülbağ, Duygu Yılmaz Usta, Hazal E. Gültekin, Ayşe N. Oktay, Özden Demirtaş, Alptuğ Karaküçük, Nevin Çelebi, "New Perspective to Develop Memantine Orally Disintegrating Tablet Formulations: SeDeM Expert System", Pharmaceutical Development and Technology, 2018, 23(5), 512,519.
Emine Taşhan, Alptuğ Karaküçük, Nevin Çelebi, "Ağızda Dağılan Tabletler: Genel Bakış ve Tasarımla Kalite (QbD) Yaklaşımı", Turkiye Klinikleri Journal of Pharmaceutical Sciences, 2017, 6(1), 43-58.
Alptug Karakucuk, Nevin Celebi, Zeynep Safak Teksin, "Preparation of ritonavir nanosuspensions by microfluidization using polymeric stabilizers: I. A Design of Experiment approach", European Journal of Pharmaceutical Sciences, 2016, 95, 111-121.
Alptug Karakucuk, Emine Tashan, Naile Ozturk, Nevin Celebi, "In Vitro Caco-2 Cell Permeability Studies of Ziprasidone Hydrochloride Monohydrate Nanocrystals", Turkish Journal of Pharmaceutical Sciences, 10.4274/tjps.galenos.2020.67366.
Diren Sarısaltık-Yasin, Alev Arslanturk-Bingul, Alptug Karakucuk, Zeynep Safak Teksin, "Development and validation of an HPLC method using an experimental design for analysis of amlodipine besylate and enalapril maleate in a fixed dose combination", Turkish Journal of Pharmaceutical Sciences, 10.4274/tjps.galenos.2020.89725.
Alptug Karakucuk, Nevin Celebi, "Investigation of Formulation and Process Parameters of Wet Media Milling to Develop Etodolac Nanosuspensions", Pharmaceutical Research, 2020, 37, 1-18.
Emine Tashan, Alptug Karakucuk, Nevin Celebi, " Development of Nanocrystal Ziprasidone Orally Disintegrating Tablets: Optimization by Using Design of Experiment and In Vitro Evaluation", AAPS PharmSciTech, 2020, 21, 1-12.
Ayşe N. Oktay, Sibel Ilbasmis-Tamer, Alptug Karakucuk, Nevin Celebi, "Screening of stabilizing agents to optimize flurbiprofen nanosuspensions using experimental design", Journal of Drug Delivery Science and Technology, 2020, 101690.
Emine Tashan, Alptug Karakucuk, Nevin Celebi, "Optimization and in vitro evaluation of ziprosidone nanosuspensions produced by a top-down approach", Journal of Drug Delivery Science and Technology, 2019, 52, 37-45.
Alptug Karakucuk, Zeynep Safak Teksin, Hakan Eroglu, Nevin Celebi, “Evaluation of improved oral bioavailability of ritonavir nanosuspension”, European Journal of Pharmaceutical Sciences, 2019, 131, 153-158.
Zarith Asyikin Abdul Aziz, Akil Ahmad, Siti Hamidah Mohd Setapar, Alptug Karakucuk, Muhammad Mohsin Azim, David Lokhat, Mohammad Amjad Kamal, Ghulam Md. Ashraf, "Essential Oils: Extraction Techniques, Pharmaceutical And Therapeutic Ptential - A Review", Current Drug Metabolism, 2018, 19(13), 1100-1110, DOI:10.2174/1389200219666180723144850.
Ayşe N. Oktay, Alptug Karakucuk, Sibel Ilbasmis-Tamer, Nevin Celebi, "Dermal flurbiprofen nanosuspensions: Optimization with design of experiment approach and in vitro evaluation", European Journal of Pharmaceutical Sciences, 2018, 122, 254-263.
Sıla Gülbağ, Duygu Yılmaz Usta, Hazal E. Gültekin, Ayşe N. Oktay, Özden Demirtaş, Alptuğ Karaküçük, Nevin Çelebi, "New Perspective to Develop Memantine Orally Disintegrating Tablet Formulations: SeDeM Expert System", Pharmaceutical Development and Technology, 2018, 23(5), 512,519.
Emine Taşhan, Alptuğ Karaküçük, Nevin Çelebi, "Ağızda Dağılan Tabletler: Genel Bakış ve Tasarımla Kalite (QbD) Yaklaşımı", Turkiye Klinikleri Journal of Pharmaceutical Sciences, 2017, 6(1), 43-58.
Alptug Karakucuk, Nevin Celebi, Zeynep Safak Teksin, "Preparation of ritonavir nanosuspensions by microfluidization using polymeric stabilizers: I. A Design of Experiment approach", European Journal of Pharmaceutical Sciences, 2016, 95, 111-121.
Patent/ Faydalı Model/ Marka Tescil
Alptuğ Karaküçük, Nevin Çelebi, Serdar Tort, "Etodolak Nanosüspansiyonu İçeren Jel Formülasyonu", 2020/06378, patent (başvuru).
22/10/2018, Serdar Tort, Alptuğ Karaküçük, Fiber Farma İlaç Kozmetik Tıbbi Cihazlar ve Danışmanlık Ltd. Şti. "Kitozan ve PVP Nanolifleri İçeren Kanama Durdurucu Örtü", 2016/16139, patent.
21/06/2018, Nevin Çelebi, Emine Taşhan, Alptuğ Karaküçük, "Ziprasidon Hidroklorür Monohidrat (ZHM) Liyofilize Nanosüspansiyon Formülasyonu", 2017/03057 B, incelemeli patent.
23/10/2017, Nevin Çelebi, Alptuğ Karaküçük, Zeynep Şafak Teksin, "Ritonavir İçeren Liyofilize Nanosüspansiyon Formülasyonu", 2016/02454 B, incelemeli patent.
07/06/2016, Fiber Farma İlaç Kozmetik Tıbbi Cihazlar Eğitim ve Danışmanlık, "RESCARE", 2016/50333, Marka Tescili.
22/10/2018, Serdar Tort, Alptuğ Karaküçük, Fiber Farma İlaç Kozmetik Tıbbi Cihazlar ve Danışmanlık Ltd. Şti. "Kitozan ve PVP Nanolifleri İçeren Kanama Durdurucu Örtü", 2016/16139, patent.
21/06/2018, Nevin Çelebi, Emine Taşhan, Alptuğ Karaküçük, "Ziprasidon Hidroklorür Monohidrat (ZHM) Liyofilize Nanosüspansiyon Formülasyonu", 2017/03057 B, incelemeli patent.
23/10/2017, Nevin Çelebi, Alptuğ Karaküçük, Zeynep Şafak Teksin, "Ritonavir İçeren Liyofilize Nanosüspansiyon Formülasyonu", 2016/02454 B, incelemeli patent.
07/06/2016, Fiber Farma İlaç Kozmetik Tıbbi Cihazlar Eğitim ve Danışmanlık, "RESCARE", 2016/50333, Marka Tescili.
Oral Sunumlar/ Davetli Konuşmacı
Samet Ozdemir, Alptug Karakucuk, "Design and evaluation of oral mucoadhesive films for pharmaceuticals that have poor oral bioavailability", 4th International Medicine and Health Sciences Researchers Congress, August 22-23, 2020, Çorum, Turkey.
Alptug Karakucuk, "Solubility enhancement of poorly soluble drugs: A design of experiment approach to develop nanosuspensions", 23rd International Conference and Exhibition on Pharmaceutical Formulations, July 27-28, 2020, Webinar.
Diren Sarisaltik-Yasin, Alev Arslanturk-Bingul, Alptug Karakucuk, Zeynep Safak Teksin, "Development and validation of an HPLC method for amlodipine besylate and enalapril maleate using an experimental design and its application to solubility and dissolution tests", 12th of International Symposium on Pharmaceutical Sciences (ISOPS), June 26-29, 2018, Ankara, Turkey.
Sila Gulbag, Alptug Karakucuk, Basaran Mutlu-Agardan, Nevin Celebi, "Top down production of cyclosporine A nanosuspensions for oral delivery: formulation design and characterization", European Federation For Pharmaceutical Sciences (EUFEPS) Annual Meeting 2018, May 24-26, 2018, Athens, Greece.
Serdar Tort, Alptug Karakucuk, "Akademik Girişimcilik", Davetli Konuşmacı, Gazi Üniversitesi Eczacılık Fakültesi FarmaEkol Öğrenci Topluluğu Sempozyumu (GaziFarmaSem), 30-31 Mart 2018, Ankara, Türkiye.
Aysenur Oktay, Alptug Karakucuk, Sibel Isbasmis-Tamer, Nevin Celebi, "Optimization of flurbiprofen nanosuspensions with polymeric stabilizers for dermal application", GPSS International Gazi Pharma Symposium Series 2, October 11-13, 2017, Ankara, Turkey.
Aysenur Oktay, Alptug Karakucuk, Sibel Isbasmis-Tamer, Nevin Celebi, "Optimization of flurbiprofen nanosuspensions: The QbD Approach", 7th BBBB International Conference on Pharmaceutical Sciences, October 5-7, 2017, Balatonfüred, Hungary.
Fiber Farma İl. Koz. Dan., "Kitozan ve PVP Kompozit Nanofiber Tabanlı Kanama Durdurucu Örtü Geliştirilmesi", Bio Startup Mena Hızlandırıcı Programı 2017 Dönemi, TEPAV, 25 Mayıs 2017, Ankara, Türkiye
Alptug Karakucuk, "Chitosan and PVP Composite Nanofiber Based Haemostatic Dressing", Royal Academy of Engineering, Leaders In Innovation Fellowships, February 13-24, 2017, London, UK.
Alptuğ Karaküçük, Nevin Çelebi, "Preparation of ritonavir nanosuspensions by micro-fluidization method using polymeric stabilizers: I. A design of experiment approach", 6th BBBB - Conference on Pharmaceutical Sciences: Strategies to Improve the Quality and Performance of Modern Drug Delivery Systems, September 10-12, 2015, Helsinki, Finland.
Alptug Karakucuk, "Solubility enhancement of poorly soluble drugs: A design of experiment approach to develop nanosuspensions", 23rd International Conference and Exhibition on Pharmaceutical Formulations, July 27-28, 2020, Webinar.
Diren Sarisaltik-Yasin, Alev Arslanturk-Bingul, Alptug Karakucuk, Zeynep Safak Teksin, "Development and validation of an HPLC method for amlodipine besylate and enalapril maleate using an experimental design and its application to solubility and dissolution tests", 12th of International Symposium on Pharmaceutical Sciences (ISOPS), June 26-29, 2018, Ankara, Turkey.
Sila Gulbag, Alptug Karakucuk, Basaran Mutlu-Agardan, Nevin Celebi, "Top down production of cyclosporine A nanosuspensions for oral delivery: formulation design and characterization", European Federation For Pharmaceutical Sciences (EUFEPS) Annual Meeting 2018, May 24-26, 2018, Athens, Greece.
Serdar Tort, Alptug Karakucuk, "Akademik Girişimcilik", Davetli Konuşmacı, Gazi Üniversitesi Eczacılık Fakültesi FarmaEkol Öğrenci Topluluğu Sempozyumu (GaziFarmaSem), 30-31 Mart 2018, Ankara, Türkiye.
Aysenur Oktay, Alptug Karakucuk, Sibel Isbasmis-Tamer, Nevin Celebi, "Optimization of flurbiprofen nanosuspensions with polymeric stabilizers for dermal application", GPSS International Gazi Pharma Symposium Series 2, October 11-13, 2017, Ankara, Turkey.
Aysenur Oktay, Alptug Karakucuk, Sibel Isbasmis-Tamer, Nevin Celebi, "Optimization of flurbiprofen nanosuspensions: The QbD Approach", 7th BBBB International Conference on Pharmaceutical Sciences, October 5-7, 2017, Balatonfüred, Hungary.
Fiber Farma İl. Koz. Dan., "Kitozan ve PVP Kompozit Nanofiber Tabanlı Kanama Durdurucu Örtü Geliştirilmesi", Bio Startup Mena Hızlandırıcı Programı 2017 Dönemi, TEPAV, 25 Mayıs 2017, Ankara, Türkiye
Alptug Karakucuk, "Chitosan and PVP Composite Nanofiber Based Haemostatic Dressing", Royal Academy of Engineering, Leaders In Innovation Fellowships, February 13-24, 2017, London, UK.
Alptuğ Karaküçük, Nevin Çelebi, "Preparation of ritonavir nanosuspensions by micro-fluidization method using polymeric stabilizers: I. A design of experiment approach", 6th BBBB - Conference on Pharmaceutical Sciences: Strategies to Improve the Quality and Performance of Modern Drug Delivery Systems, September 10-12, 2015, Helsinki, Finland.
Bildiriler
Sila Gulbag, Alptug Karakucuk, Basaran Mutlu-Agardan, Nevin Celebi, "The Effect of Process Parameters of the Cyclosporine A Nanosuspension Produced by Wet Milling Stabilized with Hydroxypropyl methylcellulose", Controlled Release Society (CRS) Annual Meeting & Exposition, July 21-24, 2019, Valencia, Spain.
Aysenur Oktay, Alptug Karakucuk, Sibel Isbasmis-Tamer, Nevin Celebi, "Optimization of Dermal Flurbiprofen Nanosuspension using Design of Experiment (DoE): Development by Wet Milling", AAPS PharmSci 360 Advancing Pharmaceutical Sciences, Carriers and Communities, November 4-7, 2018, Washington DC, USA.
Aysenur Oktay, Sibel Isbasmis-Tamer, Alptug Karakucuk, Nevin Celebi, "Evaluation of Dermal Permeation of Flurbiprofen-Nanosuspension Based Gel Systems, 19th. International Pharmaceutical Technology Symposium (IPTS)", September 17-19, 2018, Antalya/Turkey.
Emine Tashan, Alptug Karakucuk, Naile Ozturk, Nevin Celebi, "In-vitro Caco-2 Permeability Studies of Ziprasidone Hydrochloride Monohydrate Nanosuspensions", 19th International Pharmaceutical Tehnology Symposium (IPTS), September 17-19, 2018, Antalya, Turkey.
Sila Gulbag, Alptug Karakucuk, Basaran Mutlu-Agardan, Nevin Celebi, "Preformulation studies of cyclosporine A nanosuspension stabilized by hydroxypropyl methylcellulose and soluplus®", 12th of International Symposium on Pharmaceutical Sciences (ISOPS), June 26-29, 2018, Ankara, Turkey.
Aysenur Oktay, Alptug Karakucuk, Sibel Isbasmis-Tamer, Nevin Celebi, "The effect of polymeric stabilizer on stability of optimum flurbiprofen nanosuspension", 12th of International Symposium on Pharmaceutical Sciences (ISOPS), June 26-29, 2018, Ankara, Turkey.
Aysenur Oktay, Alptug Karakucuk, Sibel Isbasmis-Tamer, Nevin Celebi, "Evaluation of solubility and dermal permeation of flurbiprofen nanosuspension", European Federation For Pharmaceutical Sciences (EUFEPS) Annual Meeting 2018, May 24-26, 2018, Athens, Greece.
Alptug Karakucuk, Hakan Eroglu, Zeynep Safak Teksin, Nevin Celebi, "Preparation and analysis of in vitro- in vivo correlation of ritonavir nanosuspensions", European Federation For Pharmaceutical Sciences (EUFEPS) Annual Meeting 2018, May 24-26, 2018, Athens, Greece.
Sila Gulbag, Alptug Karakucuk, Basaran Mutlu-Agardan, Nevin Celebi, "Preparation and characterization of cyclosporine A nanosuspension for oral administration II: The effect of Poloxamer types on physical stability of formulations", 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, March 19-22, 2018, Granada, Spain.
Aysenur Oktay, Alptug Karakucuk, Sibel Isbasmis-Tamer, Nevin Celebi, "Optimization of flurbiprofen nanosuspensions using full factorial design for dermal application", 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, March 19-22, 2018, Granada, Spain.
Sila Gulbag, Alptug Karakucuk, Nevin Celebi, "Preparation and characterization of cyclosporine nanosuspension for oral administration I: Effects of formulation parameters", GPSS International Gazi Pharma Symposium Series 2, October 11-13, 2017, Ankara, Turkey.
Merve Celik Tekeli, Alptug Karakucuk, Yesim Aktas, Nevin Celebi, "Development of a self emulsifying drug delivery system by design of experiment (DoE) approach", GPSS International Gazi Pharma Symposium Series 2, October 11-13, 2017, Ankara, Turkey.
Emine Tashan, Alptug Karakucuk, Nevin Celebi, "Preparation of orally dispersible tablets of ziprasidone hydrochloride monohydrate nanocrystals: The Quality by Design (QbD) approach", 7th BBBB International Conference on Pharmaceutical Sciences, October 5-7, 2017, Balatonfüred, Hungary.
Alptug Karakucuk, Zeynep Safak Teksin, Nevin Celebi, "Evaluation of fasted and fed bioavailabilities of ritonavir nanosuspension in rats", Controlled Release Society Annual Meeting & Exposition, July 16-19, 2017, Boston, Massachusetts, USA.
Alptug Karakucuk, Naile Ozturk, Imran Vural, Zeynep Safak Teksin, Nevin Celebi, "In vitro CACO-2 cell permeability studies of ritonavir nanosuspension formulation", 6th FIP Pharmaceutical Sciences World Congress 2017, May 21-24, 2017, Stockholm, Sweden.
Serdar Tort, Alptug Karakucuk, Nevin Celebi, Fusun Acarturk, "Electrospun PCL Nanofiber composites of resveratrol nanocrystals: Production, Characterization and Antimicrobial Activity", 6th FIP Pharmaceutical Sciences World Congress 2017, May 21-24, 2017, Stockholm, Sweden.
Alptug Karakucuk, Hande Canpinar, Nevin Celebi, "Determination of lymphoctye sub-groups after administration of ritonavir nanosuspensions orally using flow cytometry", The 22nd Biomedical Science and Technology Symposium (BIOMED 2017), May 12-14, 2017, Ankara, Turkey.
Emine Taşhan, Alptuğ Karaküçük, Nevin Çelebi, "Evaluation of Solubility and Dissolution Profiles of Ziprasidone Hydrochloride Monohydrate Nanosuspensions", 18th International Pharmaceutical Tehnology Symposium (IPTS), September 18-21, 2016, Antalya, Turkey.
Alptug Karakucuk, Nevin Celebi, Zeynep Teksin, "Evaluation of solubility and dissolution of ritonavir nanosuspensions", 4th Congress on Innovation in Drug Delivery Site-Spesific Drug Delivery, September 25-28, 2016, Antibes-Juan-les-Pins, France.
Alptuğ Karaküçük, Nevin Çelebi, "Characterization and optimization of ritonavir nanosuspension formulations using different stabilizers: III. Application of the factorial design", 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, April 4-7, 2016, Glasgow, United Kingdom.
Ayşe Nur Oktay, Sıla Gülbağ, Özden Demirtaş, Duygu Yılmaz Usta, Hazal Ezgi Gültekin, Alptuğ Eren Karaküçük, Nevin Çelebi "New Perspective For Memantine Orally Disintegrating Tablet: SeDeM Expert System", GPSS International Gazi Pharma Symposium Series, November 12-15, 2015, Antalya, Turkey.
Alptuğ Karaküçük, Nevin Çelebi, "Preparation and Characterization of HPMC Stabilized Nanosuspensions: II. Considering Interactions Between Formulation Parametres", 2015 AAPS Annual Meeting and Exposition, October 25-29, 2015, Orlando, USA.
Emine Taşhan, Alptuğ Karaküçük, Nevin Çelebi, "Preparation of Ziprasidone Hydrochloride Monohydrate Nanosuspensions Through Desing of Experiment (DoE)", 2015 AAPS Annual Meeting and Exposition, October 25-29, 2015, Orlando, USA.
Alptuğ Karaküçük, Nevin Çelebi, Zeynep Şafak Teksin, “Effect of stabilizers on the particle size reduction and physical stability of ritonavir nanosuspensions” 2014 AAPS Annual Meeting and Exposition, November 2-6, 2014, San Diego, USA.
Emine Taşhan, Alptuğ Karaküçük, Nevin Çelebi, “Preparation of ziprasidone nanosuspensions by microfluidization technique using different stabilizers”, 17th International Pharmaceutical Tehnology Symposium (IPTS), September 8-10, 2014, Antalya, Turkey.
Gülen Melike Demir, Alptuğ Karaküçük, Zelihagül Değim, Derya Bektaş, Özlem Çoban, Ezgi Gülpınar, Sema Tuna Torunoğlu, “Stirring Speed Effects On Physical Characteristics Of Theophylline Microsphere”, Proceedings of the 5th International Conference on Nanotechnology: Fundamentals and Applications August 11-13, 2014, Prague, Czech Republic.
Aysenur Oktay, Alptug Karakucuk, Sibel Isbasmis-Tamer, Nevin Celebi, "Optimization of Dermal Flurbiprofen Nanosuspension using Design of Experiment (DoE): Development by Wet Milling", AAPS PharmSci 360 Advancing Pharmaceutical Sciences, Carriers and Communities, November 4-7, 2018, Washington DC, USA.
Aysenur Oktay, Sibel Isbasmis-Tamer, Alptug Karakucuk, Nevin Celebi, "Evaluation of Dermal Permeation of Flurbiprofen-Nanosuspension Based Gel Systems, 19th. International Pharmaceutical Technology Symposium (IPTS)", September 17-19, 2018, Antalya/Turkey.
Emine Tashan, Alptug Karakucuk, Naile Ozturk, Nevin Celebi, "In-vitro Caco-2 Permeability Studies of Ziprasidone Hydrochloride Monohydrate Nanosuspensions", 19th International Pharmaceutical Tehnology Symposium (IPTS), September 17-19, 2018, Antalya, Turkey.
Sila Gulbag, Alptug Karakucuk, Basaran Mutlu-Agardan, Nevin Celebi, "Preformulation studies of cyclosporine A nanosuspension stabilized by hydroxypropyl methylcellulose and soluplus®", 12th of International Symposium on Pharmaceutical Sciences (ISOPS), June 26-29, 2018, Ankara, Turkey.
Aysenur Oktay, Alptug Karakucuk, Sibel Isbasmis-Tamer, Nevin Celebi, "The effect of polymeric stabilizer on stability of optimum flurbiprofen nanosuspension", 12th of International Symposium on Pharmaceutical Sciences (ISOPS), June 26-29, 2018, Ankara, Turkey.
Aysenur Oktay, Alptug Karakucuk, Sibel Isbasmis-Tamer, Nevin Celebi, "Evaluation of solubility and dermal permeation of flurbiprofen nanosuspension", European Federation For Pharmaceutical Sciences (EUFEPS) Annual Meeting 2018, May 24-26, 2018, Athens, Greece.
Alptug Karakucuk, Hakan Eroglu, Zeynep Safak Teksin, Nevin Celebi, "Preparation and analysis of in vitro- in vivo correlation of ritonavir nanosuspensions", European Federation For Pharmaceutical Sciences (EUFEPS) Annual Meeting 2018, May 24-26, 2018, Athens, Greece.
Sila Gulbag, Alptug Karakucuk, Basaran Mutlu-Agardan, Nevin Celebi, "Preparation and characterization of cyclosporine A nanosuspension for oral administration II: The effect of Poloxamer types on physical stability of formulations", 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, March 19-22, 2018, Granada, Spain.
Aysenur Oktay, Alptug Karakucuk, Sibel Isbasmis-Tamer, Nevin Celebi, "Optimization of flurbiprofen nanosuspensions using full factorial design for dermal application", 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, March 19-22, 2018, Granada, Spain.
Sila Gulbag, Alptug Karakucuk, Nevin Celebi, "Preparation and characterization of cyclosporine nanosuspension for oral administration I: Effects of formulation parameters", GPSS International Gazi Pharma Symposium Series 2, October 11-13, 2017, Ankara, Turkey.
Merve Celik Tekeli, Alptug Karakucuk, Yesim Aktas, Nevin Celebi, "Development of a self emulsifying drug delivery system by design of experiment (DoE) approach", GPSS International Gazi Pharma Symposium Series 2, October 11-13, 2017, Ankara, Turkey.
Emine Tashan, Alptug Karakucuk, Nevin Celebi, "Preparation of orally dispersible tablets of ziprasidone hydrochloride monohydrate nanocrystals: The Quality by Design (QbD) approach", 7th BBBB International Conference on Pharmaceutical Sciences, October 5-7, 2017, Balatonfüred, Hungary.
Alptug Karakucuk, Zeynep Safak Teksin, Nevin Celebi, "Evaluation of fasted and fed bioavailabilities of ritonavir nanosuspension in rats", Controlled Release Society Annual Meeting & Exposition, July 16-19, 2017, Boston, Massachusetts, USA.
Alptug Karakucuk, Naile Ozturk, Imran Vural, Zeynep Safak Teksin, Nevin Celebi, "In vitro CACO-2 cell permeability studies of ritonavir nanosuspension formulation", 6th FIP Pharmaceutical Sciences World Congress 2017, May 21-24, 2017, Stockholm, Sweden.
Serdar Tort, Alptug Karakucuk, Nevin Celebi, Fusun Acarturk, "Electrospun PCL Nanofiber composites of resveratrol nanocrystals: Production, Characterization and Antimicrobial Activity", 6th FIP Pharmaceutical Sciences World Congress 2017, May 21-24, 2017, Stockholm, Sweden.
Alptug Karakucuk, Hande Canpinar, Nevin Celebi, "Determination of lymphoctye sub-groups after administration of ritonavir nanosuspensions orally using flow cytometry", The 22nd Biomedical Science and Technology Symposium (BIOMED 2017), May 12-14, 2017, Ankara, Turkey.
Emine Taşhan, Alptuğ Karaküçük, Nevin Çelebi, "Evaluation of Solubility and Dissolution Profiles of Ziprasidone Hydrochloride Monohydrate Nanosuspensions", 18th International Pharmaceutical Tehnology Symposium (IPTS), September 18-21, 2016, Antalya, Turkey.
Alptug Karakucuk, Nevin Celebi, Zeynep Teksin, "Evaluation of solubility and dissolution of ritonavir nanosuspensions", 4th Congress on Innovation in Drug Delivery Site-Spesific Drug Delivery, September 25-28, 2016, Antibes-Juan-les-Pins, France.
Alptuğ Karaküçük, Nevin Çelebi, "Characterization and optimization of ritonavir nanosuspension formulations using different stabilizers: III. Application of the factorial design", 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, April 4-7, 2016, Glasgow, United Kingdom.
Ayşe Nur Oktay, Sıla Gülbağ, Özden Demirtaş, Duygu Yılmaz Usta, Hazal Ezgi Gültekin, Alptuğ Eren Karaküçük, Nevin Çelebi "New Perspective For Memantine Orally Disintegrating Tablet: SeDeM Expert System", GPSS International Gazi Pharma Symposium Series, November 12-15, 2015, Antalya, Turkey.
Alptuğ Karaküçük, Nevin Çelebi, "Preparation and Characterization of HPMC Stabilized Nanosuspensions: II. Considering Interactions Between Formulation Parametres", 2015 AAPS Annual Meeting and Exposition, October 25-29, 2015, Orlando, USA.
Emine Taşhan, Alptuğ Karaküçük, Nevin Çelebi, "Preparation of Ziprasidone Hydrochloride Monohydrate Nanosuspensions Through Desing of Experiment (DoE)", 2015 AAPS Annual Meeting and Exposition, October 25-29, 2015, Orlando, USA.
Alptuğ Karaküçük, Nevin Çelebi, Zeynep Şafak Teksin, “Effect of stabilizers on the particle size reduction and physical stability of ritonavir nanosuspensions” 2014 AAPS Annual Meeting and Exposition, November 2-6, 2014, San Diego, USA.
Emine Taşhan, Alptuğ Karaküçük, Nevin Çelebi, “Preparation of ziprasidone nanosuspensions by microfluidization technique using different stabilizers”, 17th International Pharmaceutical Tehnology Symposium (IPTS), September 8-10, 2014, Antalya, Turkey.
Gülen Melike Demir, Alptuğ Karaküçük, Zelihagül Değim, Derya Bektaş, Özlem Çoban, Ezgi Gülpınar, Sema Tuna Torunoğlu, “Stirring Speed Effects On Physical Characteristics Of Theophylline Microsphere”, Proceedings of the 5th International Conference on Nanotechnology: Fundamentals and Applications August 11-13, 2014, Prague, Czech Republic.
Sertifika/ Belge
T.C. Milli Savunma Bakanlığı Askeri Fabrikalar Genel Müdürlüğü, İlaç Fabrikası Müdürlüğü "Ecz. Tğm. Alptuğ Karaküçük Takdir Belgesi", Ankara, 29.03.2019.
T.C. K.K.K. Yedek Subay Adayı Temel Kursu, "Bitirme Diploması", 01.06.2018.
T.C. K.K.K. Sahra Sıhhiye Okulu Kurs Tabur Komutanlığı, "Ecz. Atğm. Ad. Öğrc. Alptuğ Eren Karaküçük Takdir Belgesi", Samsun, 30.05.2018.
Eğiticilerin Eğitimi Sertifikası, Gazi Üniversitesi Eğitim Fakültesi ve Uzaktan Eğitim Uygulama ve Araştırma Merkezi, 08.05.2017- 02.06.2017.
Fiber Farma İl. Koz. Dan., Bio Startup Mena Hızlandırıcı Programı 2017 Dönemi Eğitim ve Mentorluk Programı Katılım Belgesi, TEPAV, 25 Mayıs 2017, Ankara, Türkiye
Certificate of Completion, Leaders In Innovation Fellowships, Royal Academy of Engineering, London, UK, 2016/17.
Vücut Dili Başarı Sertifikası, Rodos Grup, 10.2016.
Etkili İletişim Başarı Sertifikası, Rodos Grup, 10.2016.
Diksiyon Başarı Sertifikası, Rodos Grup, 10.2016.
İş Sağlığı ve Güvenliği Hizmetlerinin Yürütümüne İlişkin İşveren veya İşveren Vekili Eğitimi Tamamlama Belgesi, T.C. Çalışma ve Sosyal Güvenlik Bakanlığı - Anadolu Üniversitesi, Türkiye, 05.2016.
Deney Hayvanları Kullanım Sertifikası, Gazi Üniversitesi Laboratuvar Hayvanları Yetiştirme ve Deneysel Araştırmalar Merkezi (GÜDAM), Türkiye, 12.2012.
İyi Takım Oyuncusu Olma Sertifikası, Akademisyon Danışmanlık, Türkiye, 01.2012.
Italian Language A Level Certificate, Universita Degli Di Perugia, Italia, 08.2009.
T.C. K.K.K. Yedek Subay Adayı Temel Kursu, "Bitirme Diploması", 01.06.2018.
T.C. K.K.K. Sahra Sıhhiye Okulu Kurs Tabur Komutanlığı, "Ecz. Atğm. Ad. Öğrc. Alptuğ Eren Karaküçük Takdir Belgesi", Samsun, 30.05.2018.
Eğiticilerin Eğitimi Sertifikası, Gazi Üniversitesi Eğitim Fakültesi ve Uzaktan Eğitim Uygulama ve Araştırma Merkezi, 08.05.2017- 02.06.2017.
Fiber Farma İl. Koz. Dan., Bio Startup Mena Hızlandırıcı Programı 2017 Dönemi Eğitim ve Mentorluk Programı Katılım Belgesi, TEPAV, 25 Mayıs 2017, Ankara, Türkiye
Certificate of Completion, Leaders In Innovation Fellowships, Royal Academy of Engineering, London, UK, 2016/17.
Vücut Dili Başarı Sertifikası, Rodos Grup, 10.2016.
Etkili İletişim Başarı Sertifikası, Rodos Grup, 10.2016.
Diksiyon Başarı Sertifikası, Rodos Grup, 10.2016.
İş Sağlığı ve Güvenliği Hizmetlerinin Yürütümüne İlişkin İşveren veya İşveren Vekili Eğitimi Tamamlama Belgesi, T.C. Çalışma ve Sosyal Güvenlik Bakanlığı - Anadolu Üniversitesi, Türkiye, 05.2016.
Deney Hayvanları Kullanım Sertifikası, Gazi Üniversitesi Laboratuvar Hayvanları Yetiştirme ve Deneysel Araştırmalar Merkezi (GÜDAM), Türkiye, 12.2012.
İyi Takım Oyuncusu Olma Sertifikası, Akademisyon Danışmanlık, Türkiye, 01.2012.
Italian Language A Level Certificate, Universita Degli Di Perugia, Italia, 08.2009.